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Robert N. Averbuch, MD Alan J. Barnes, MD Lewis R. Baxter, MD Adriaan W. Bruijnzeel, PhD Regina Bussing, MD Josepha A. Cheong, MD Wayne L. Creelman, MD Douglas Davies, MD Gary R. Geffken, PhD Mark S. Gold, MD William M. Greene, MD Susan Hill, MSN, ARNP Jon Hodgin, MD Richard Holbert, MD Jacqueline A. Hobbs, MD, PhD Michelle Jacobs, MD Mark H. Lewis, PhD Yijun Liu, PhD Daniel Logan, MD Ross A. McElroy, Jr., MD Lisa J. Merlo, PhD Sylvia P. Montesinos, MD Drake Morgan, PhD Matthew L. Nguyen, MD Andrew K. Ottens, PhD John M. Petitto, MD Teresa A. Pigott, MD Krestin A. Radonovich, PhD Jerzy Szlabowicz, MD, PhD Scott A. Teitelbaum, MD Herbert E. Ward, MD Tonia Werner, MD Kimberly White, MD

Andrew K. Ottens

Andrew K. Ottens Ph.D.

Assistant Professor

Dr. Andrew Ottens

Dr. Ottens graduated with distinction from the College of New Jersey with a Baccalaureate in Chemistry. He went on to receive his Doctorate Degree from the University of Florida in Chemistry, specializing in analytical science and technology. He was awarded the Linton E. Grinter and Roger G. and Jo Bates Fellowships, as well as honored with an exclusive research internship at the NASA Kennedy Space Center, for which he later received a NASA Space Act Award. Dr. Ottens then completed his postdoctoral research in Neuroscience, applying analytical technology for biomarker discovery in traumatic brain injury. He joined the Department of Neuroscience faculty of the College of Medicine at the University of Florida in 2004, attaining the position of Research Assistant Professor before joining the Department of Psychiatry in 2006 as an Assistant Professor. He has an adjunct appointment in the Department of Neuroscience.

Research Interests and Scholarly Interests

Dr. Ottens’ research is currently focused on integrating bioanalytical science and technology for the characterization of protein chemistry perturbation in the brain following injury by trauma or toxic substances. He is currently funded by the National Institute for Neurological Disorders and Stroke (NINDS/NIH) to develop new chemistry for characterization of protein proteolysis following brain injury. Recently, Dr. Ottens has begun to examine the impact of secondhand smoke as a toxic substance in the brain, with particular interest in the effects on the developing brain. A particular focus of his research involves proteomics and the use of analytical separations and mass spectrometry.

Educational Interests and Accomplishments

Dr. Ottens is a member of the University of Florida Graduate School and an active participant in graduate education and mentoring. In addition to graduate students, Dr. Ottens has mentored undergraduate students and post-doctorates interested in health related research. He also routinely gives guest lectures and seminars.

Leadership And Service

Dr. Ottens has taken a leadership role as the Associate Director of the Center for Neuroproteomics and Biomarkers Research and Scientific Director of the Neuroproteomics Bioanalytical Laboratory for the Center for Traumatic Brain Injury Studies at the McKnight Brain Institute. Dr. Ottens serves as a member of the Subcommittee for Research Safety at the Department of Veterans Affairs Gainesville Medical Center, Florida. He is also a member-at-large of the Shands Cancer Center and the McKnight Brain Institute at the University of Florida, both renowned nationally. Dr. Ottens continues to serve as an ad hoc reviewer for peer reviewed publications and funding agencies.

Selected Publications

Arkin CR, Griffin TP, Ottens AK, Diaz JA, Follistein DW, Adams FW, Helms WR. Evaluation of small mass spectrometer systems for permanent gas analysis. J Am Soc Mass Spectrom. 13(8):1004-12, 2002.

Ottens AK, Harrison WW, Griffin TP, Helms WR. Real-time quantitative analysis of H2, He, O2, and Ar by quadrupole ion trap mass spectrometry. J Am Soc Mass Spectrom. 13(9):1120-8, 2002.

Ottens AK, Arkin CR, Griffin TP, Palmer PT, Harrison WW. Ion-molecule reactions in quadrupole ion trap mass spectrometry: implications for lightweight gas analysis. Int J Mass Spectrom. 243(1):33-39, 2005.

Haskins WE, Kobeissy FH, Wolper RA, Ottens AK, Kitlen JW, Liu MC, McClung SH, Lundberg AG, O’Steen BE, Chow MM, Pineda JA, Denslow ND, Hayes RL, Wang KKW. Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry. J Neurotrauma. 22(6):629-644, 2005.

Ottens AK, Kobeissy FH, Wolper RA, Haskins WE, Hayes RL, Denslow ND, Wang KKW. A Multidimensional Differential Proteomic Platform Using Dual Phase Ion-Exchange Chromatography - Polyacrylamide Gel Electrophoresis/Reverse Phase Liquid Chromatography Tandem Mass Spectrometry. Anal Chem. 77(15):4836-4845, 2005.

Wang KKW, Ottens AK, Liu MC, Lewis SB, Meegan C, Oli MW, Tortella FC, Hayes RL, Proteomic identification of biomarkers of traumatic brain injury. Expert Rev Proteomics 2(4):603-614, 2005.

Wang KK, Ottens AK, Liu MC, Lewis SB, Meegan C, Oli MW, Tortella FC, Hayes RL. Proteomic identification of biomarkers of traumatic brain injury. Expert Rev Proteomics. 2(4):603-14, 2005.

Kobeissy FH, Wang  KKW, Demetree JM, Ottens AK, Zhang Z, Warrens M, Gold MS. Club Drugs: They're All the Rave: A Review of Use and Abuse: Effects of MDMA, Methamphetamine, and Gamma-Hydroxy-Butyrate (GHB) on Memory. Law Enforcement Executive Forum. 5(5):115-125, 2005.

Zhang Z, Ottens AK, Golden EC, Hayes RL, Wang KKW. Using calmodulin-affinity capture to study the rat brain calmodulin binding proteome and its vulnerability to calpain and caspase proteolysis. Cal. Bind. Proteins, 1(2):125-129, 2006.

Ottens AK, Kobeissy FH, Haskins WE, Golden EC, Zhang ZQ, Chen S, Hayes RL, Wang KKW, Denslow ND. Neuroproteomics in Neurotrauma. Mass Spectrom Rev. 25(3):380-408, 2006.

Kobeissy FH, Ottens AK, Zhang Z, Liu MC, Denslow ND, Dave JR, Tortella FC, Hayes RL, Wang KK. Novel Differential Neuroproteomics Analysis of Traumatic Brain Injury in Rats. Mol Cell Proteomics. 5(10):1887-1898, 2006. Epub 2006 Jun 26.

Zhang Z, Ottens AK, Larner SF, Kobeissy FH, Williams ML, Hayes RL, Wang KK. Direct Rho-associated kinase inhibiton induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells. Cell Mol Biol Lett. 11(1):12-29, 2006.

Svetlov SI, Xiang Y, Oli MW, Foley DP, Huang G, Hayes RL, Ottens AK, Wang KK. Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches. Biomarkers. 11(4):355-69, 2006.

Kobeissy FH, Ottens AK, Zhang Z, Liu MC, Denslow ND, Dave JR, Tortella FC, Hayes RL, Wang KKW. Differential neuroproteomics analysis of traumatic brain injury utilizing a CAX-PAGE/RPLC-MSMS approach. J. Mol. Cell Proteom. 5(10):1887-1898, 2006.

Zhang Z, Ottens AK, Sadasivan S, Kobeissy FH, Fang T, Hayes RL, Wang KK. Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury. J Neurotrauma. 2007 Mar;24(3):460-72.

Ottens AK, Kobeissy FH, Fuller BF, Liu MC, Oli MW, Hayes RL, Wang KK. Novel neuroproteomic approaches to studying traumatic brain injury. Prog Brain Res. 2007;161:401-18.

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